One of the most challenging aspects of caring for Klinefelter Syndrome men is helping them with fertility. The multi-specialty clinic has been setup with this particular focus. Below is research in this field produced by the clinic lead, Tet Yap, Consultant Urologist with specialist interest in male factor subfertility.
Hormone stimulation prior to MicroTESE improves success rates in Klinefelter Syndrome Patients (The Journal of Urology (Supplement 4) · April 2019) Click here to view
Klinefelter syndrome and success of sperm retrieval (M. Kulkarni, T Yap. BJUi Knowledge modules, 2018) Click here to view
Fertility management in testicular cancer: the need to establish a standardized and evidence-based patient-centric pathway. (Moody JA, Ahmed K, Yap T, Minhas S, Shabbir M. BJU Int. 2019) Click here for link
Identifying pathway delays and patient needs to optimize the management of men with Klinefelter Syndrome (The Journal of Urology April 2020) Click here to view
Reporting on longitudinal live birth rates and cumulative delivery rates are more realistic outcome measures than sperm retrieval rates in couples undergoing mTESE-ICSI. (Almekaty Ket al. Hum Fertil (Camb). 2018) Click here for link
A UK multicentre study analysing the surgical sperm retrieval rates in men with non-mosaic Klinefelters syndrome undergoing mTESE (P. Sangster et al, EUA congress 2018; AUA congress 2018) Click here for link
Cytogenetic abnormalities in men with sub-fertility. Analysis of the frequency of abnormalities and determination of a threshold sperm concentration for genetic testing (Yap et al. EAU congress 2015) Click here for link
Live birth rates in men undergoing microdissection TESE in non-obstructive azoospermia (NOA) (Albumelha et al. EAU congress 2016) Click here for link
Does hormonal therapy improve sperm retrieval rates in men with non-obstructive azoospermia: a systematic review and meta-analysis. (Human reproduction update Sep 2022) Click here for link
Fertility in Klinefelter Syndrome: The Need for a Multidisciplinary Approach. Tet Yap. (Frontiers in Rep Med Jan 2022) Click here for link
18 F-FDG PET/CT use in functional assessment of the testes: A systematic review( Yap T et al Andrology. 2021) Click here for link
The semen microbiome and its impact on sperm function and male fertility: A systematic review and meta-analysis( Andrology 2021) Click here for link
Age-related urologic problems in the complex urologic patient (World J Urol 2021) Click here for link
The negative impact of timed intercourse in infertile couples: A prospective cohort study (Journal of Clinical Urology 2022) Click here for link
How good are current assessment tools for gender dysphoria in Klinefelter syndrome? (International KS Workshop, Leiden 2022 C Jakes)Tet Yap
Gender identity and KS : A Systematic Review (International KS Workshop, Leiden 2022 M Vecchio) Tet Yap
Update on surgical sperm retrieval and assisted conception outcomes in patients with Klinefelter syndrome; hormone stimulation (International KS Workshop, Leiden 2022 A Murray)Tet Yap
The psychosexual impact of Klinefelter Syndrome (International KS Workshop, Leiden 2022) M Abdel Latif, Tet Yap
Patient information sheets for hormone stimulation in Klinefelter syndrome(International KS Workshop, Leiden 2022) M Abdel Latif, Tet Yap
Clinician Awareness of DVT risk in Klinefelter Syndrome(International KS Workshop, Leiden 2022)R El Nabawary, Tet Yap
Timed Intercourse increases sexual dysfunction couples compared with regular intercourse. July 2022 ESHRE (Human Reproduction)Tet Yap
Are Couples presenting to a fertility clinic truly infertile? February 2022 July 2022 ESHRE (Human Reproduction) K Khoja, S Dasgupta, L Frodsham Tet Yap
How much do varicoceles contribute to DNA fragmentation? February 2022 July 2022 ESHRE (Human Reproduction) M Nyantakyi, S Lewis, Tet Yap
Gender Identity and Questioning in Klinefelter's Syndrome,Valerie et al (BJPsych Open) 2022 Click here for link
Surgical sperm retrieval and assisted conception outcomes in patients with Klinefelter syndrome with /without hormone stimulation; S. Rintoul-Hoad et al. June 2022 BJUi
Can artificial intelligence enhance clinical outcomes and patient flow in a urology walk-in clinic? Jonathan Charnock et al. June 2022 BJUi Click here for link
Gender identity and questioning in klinefelter syndrome.Royal college of psychiatrists international congress 2022 Edinburgh
Video tuition of intracavernosal alprostadil injection for management of erectile dysfunction.P Sluzak et al.British Journal of Surgery 2020 -Prize winning abstract-Click here for link
The first year of a national-access adult Klinefelter's Syndrome multi-disciplinary team (KSMDT) clinic: patient and clinician reported outcomes. M Al-Hussini et al.May 2022 J Sex Med Click here for link
Psychosexual issue affecting men with Klinefelter Syndrome seeking fertility management. M Al-Hussini,et al.May 2022 J Sex Med Click here for link
PD49-12 AWARENESS OF VTE RISK IN KLINEFELTER SYNDROME AND TESTOSTERONE THERAPY. S. Rintoul-Hoad et al.May 2022 J Urology Click here for link
Patient Perspectives in Klinefelter Syndrome Management. R Baksi et al.May 2022 J urology R-prize winning presentation-
Digital inequalities in urological and healthcare websites: a comparison of UK, US and European digital sites February 2022 European Urology. S Kumarasingh et al.
Delayed ejaculation : an often missed diagnosis in infertile men February 2022 European Urology R Ahmed et al.Click here for link
The awareness of thromboembolic risk amongst Klinefelter Syndrome (47, XXY) patients- a clot in the knowledge? February 2022 European Urology. S. Birch et al. Click here for link
MP46-19 DETAILING SEXUAL OUTCOMES AFTER FOCAL THERAPY FOR LOCALISED PROSTATE CANCER: A SYSTEMATIC REVIEW AND META- ANALYSIS.Gaelle Fiard et al September 2021.The Journal of urology.Click here for link
MP31-20 LIVE BIRTH RATE OUTCOMES IN MEN WITH NON-OBSTRUCTIVE AZOOSPERMIA WITH TREATED CLINICAL VARICOCELES September 2021 The Journal of urology .Celina Pook et al Click here for link
MP31-04 DOES INTRACYTOPLASMIC MORPHOLOGICALLY SELECTED SPERM INJECTION IMPROVE LIVE BIRTH RATES COMPARED TO ICSI IN MEN WITH INFERTILITY AND RAISED SPERM DNA FRAGMENTATION? September 2021 The Journal of urology Runzhi Chen et al Click here for link
MP40-19 TESTICULAR CANCER: IMPACT ON PREOPERATIVE SEMEN PARAMETERS AND PREDICTIVE FACTORS FOR INFERTILITY September 2021 The Journal of urology , Musaab Yassin et al.Click here for link
MP31-09 THROMBOEMBOLIC RISK WITH THE USE OF TESTOSTERONE THERAPY IN KLINEFELTER SYNDROME September 2021. The Journal of urology. Sophie Birch et al. Click here for link
MP47-01 THE ESTABLISHMENT OF A MULTI-SPECIALTY CLINIC FOR YOUNG PEOPLE WITH KLINEFELTER’S SYNDROME. September 2021 The Journal of urology. Aminah Chowdhury et al.Click here for link
MP31-13 PREGNANCY AND LIVE BIRTH RATE OUTCOMES IN INFERTILE MEN WITH NON-OBSTRUCTIVE AZOOSPERMIA UNDERGOING HORMONE STIMULATION THERAPY. September 2021 The Journal of urology. Mohamed Al-Hussini et al.Click here for link
Early surgical outcomes following 400 feminising genital reconstructive surgeries performed by a single urological surgeon June 2021 European Urology Walters U et al.Click here for link
PROGRESS (Patient Reported Outcomes in Genital Reconstructive Surgeries): A validated patient reported outcome measure questionnaire to assess post-operative functional improvement following feminising genital reconstructive surgery June
2021 European Urology Kanthabalan A et al.Click here for link
A cohort study on thromboembolic risk with the use of testosterone therapy in Klinefelter syndrome June 2021 European Urology Melling F et al.Click here for link
Identifying the differential effects of sperm DNA fragmentation on the reproductive cycle in couples undergoing IVF and ICSI June 2021 European Urology Abdallah M et al. Click here for link
Does intracytoplasmic morphologically selected sperm injection improve live birth rates compared to ICSI in men with infertility and raised sperm DNA fragmentation? June 2021 European Urology. Chen R et al.Click here for link
How Successful Is Surgical Sperm Retrieval in Klinefelter Syndrome? Yamini Kailash et al. Front. Reprod. Health, February 2021.Click here for link
Editorial: Fertility in Klinefelter Syndrome: The Need for a Multidisciplinary Approach.Tet Yap. Front. Reprod. Health,November 2021Click here for link
Klinefelter Syndrome and the Need for a Multi-Disciplinary Approach.Andreas Espehana,Charlotte Tomlinson.Front. Reprod. Health, April 2021.Click here for link
The Evidence for Fertility Preservation in Pediatric Klinefelter Syndrome.Celina J. Pook et al.MINI REVIEW articleFront. Reprod. Health, August 2021.Click here for link
Indeterminate Lesions of the Testis in Klinefelter Syndrome—Should We Be Concerned? Nye Rhys Potter et al. Front. Reprod. Health, June 2021.Click here for link
The Impact and Management of Gynaecomastia in Klinefelter Syndrome.Amr Abdel Raheem et al. MINI REVIEW article Front. Reprod. Health, February 2021.Click here for link
Male infertility and the effect of seminal and urinary infections on sperm DNA fragmentation, reactive oxygen species and WHO semen parameters June 2021 European Urology Ho C.L.T et al.Click here for link
The development of a novel therapeutic pathway for painful nocturnal erections European Urology Open Science July 2020 Tomita K et al.Click here for link
The impact of total motile sperm count on IVF/ICSI outcomes: Is total motile sperm count a better parameter than sperm morphology? European Urology Open Science July 2020 Tharu Tharakan et al.Click here for link
Should clinical varicoceles in non-obstructive azoospermia be treated? European Urology Open Science July 2020
Pook C et al.Click here for link
MP38-10 CAN WE PREDICT FERTILITY WITH THE USE OF IMAGING? AN UPDATE ON FUNCTIONAL IMAGING OF RAT TESTES WITH PET/CT April 2020 The Journal of Urology Antoni Bochinski et al.Click here for link
MP44-04 IDENTIFYING PATHWAY DELAYS AND PATIENT NEEDS TO OPTIMIZE THE MANAGEMENT OF MEN WITH ADULT KLINFELTER SYNDROME April 2020, The Journal of Urology Andreas Espehana et al.Click here for link
MP44-01 THE IMPACT OF TOTAL MOTILE COUNT ON IVF/ICSI OUTCOMES: IS TOTAL MOTILE COUNT A BETTER PARAMETER THAN SPERM MORPHOLOGY? April 2020 The Journal of Urology. Deepa Dodia et al.Click here for link